25-hydroxyvitamin D-1alpha-hydroxylase in normal and malignant colon tissue.

@article{Tangpricha200125hydroxyvitaminDI,
  title={25-hydroxyvitamin D-1alpha-hydroxylase in normal and malignant colon tissue.},
  author={Vin Tangpricha and John N. Flanagan and Lyman W. Whitlatch and Chi Chuan Tseng and Tai Chih Chen and Peter R. Holt and Mikhail Semenovich Lipkin and Michael F Holick},
  journal={Lancet},
  year={2001},
  volume={357 9269},
  pages={
          1673-4
        }
}
Vitamin D affects calcium metabolism and prevents proliferation of colon cells in vitro. In human beings the main circulating form of vitamin D is 25-hydroxyvitamin D; to regulate calcium homoeostasis, this form must be converted to 1alpha, 25-dihydroxyvitamin D by 1alpha-hydroxylation in the kidney with 25-hydroxyvitamin D-1alpha-hydroxylase. Cultured transformed colon cancer cells can convert 25-hydroxyvitamin D(3) to 1alpha,25-dihydroxyvitamin D(3). We identified messenger RNA (mRNA) for 25… CONTINUE READING

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