25-hydroxycholecalciferol 1 alpha-hydroxylase activity in the kidney of the fetal, neonatal and adult guinea pig.

Homogenates of fetal, newborn and maternal kidney and placenta have been compared with homogenates of non-pregnant adult kidney for their ability to hydroxylate 25-hydroxycholecalciferol. The activity in the fetal kidney near term is similar to that in the mother and 4--5 times that in the non-pregnant adult. These differences from the non-pregnant adult… CONTINUE READING