25-Hydroxyvitamin D3 is a natural chemopreventive agent against carcinogen induced precancerous lesions in mouse mammary gland organ culture

@article{Peng200825HydroxyvitaminDI,
  title={25-Hydroxyvitamin D3 is a natural chemopreventive agent against carcinogen induced precancerous lesions in mouse mammary gland organ culture},
  author={Xinjian Peng and Michael L Hawthorne and Avani Vaishnav and Ren{\'e} St-Arnaud and Rajendra G. Mehta},
  journal={Breast Cancer Research and Treatment},
  year={2008},
  volume={113},
  pages={31-41}
}
Despite the role of vitamin D3 endocrine system in prevention of mammary gland transformation in animal models, use of 1,25(OH)2D3 in clinical settings is precluded due to its toxicity in vivo. Therefore much effort has been placed in developing relatively non-toxic vitamin D analogs. Recently, with the discovery of the expression of 25-hydroxy vitamin D3 1α-hydroxylase (CYP27B1) in multiple extrarenal organs, the functional role of prohormone, 25-hydroxyvitamin D3 [25(OH)D3], has been… CONTINUE READING

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