25-Hydroxycholesterols in innate and adaptive immunity

  title={25-Hydroxycholesterols in innate and adaptive immunity},
  author={Jason G Cyster and Eric V. Dang and Andrea Reboldi and Tangsheng Yi},
  journal={Nature Reviews Immunology},
Cholesterol and components of the cholesterol biosynthetic pathway have fundamental roles in all mammalian cells. Hydroxylated forms of cholesterol are now emerging as important regulators of immune function. This involves effects on the cholesterol biosynthetic pathway and cell membrane properties, which can have antiviral and anti-inflammatory influences. In addition, a dihydroxylated form of cholesterol functions as an immune cell guidance cue by engaging the G protein-coupled receptor EBI2… CONTINUE READING
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Identification and characterization of small molecule modulators of the Epstein‐Barr virus‐ induced gene 2 (EBI2) receptor

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  • 2014

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