247 Zonulin Serum Levels Are Increased in Non-Celiac Gluten Sensitivity and Irritable Bowel Syndrome With Diarrhea

  title={247 Zonulin Serum Levels Are Increased in Non-Celiac Gluten Sensitivity and Irritable Bowel Syndrome With Diarrhea},
  author={Maria Raffaella Barbaro and Cesare Cremon and Giacomo Caio and Roberto de Giorgio and Umberto Volta and Vincenzo Stanghellini and Giovanni Barbara},
Serum zonulin is elevated in IBS and correlates with stool frequency in IBS-D
Serum zonulin is upregulated in irritable bowel syndrome and the levels are comparable to those in celiac disease, suggesting no significant increase in enterocyte death.
Specific Immunoglobulin E and G to Common Food Antigens and Increased Serum Zonulin in IBS Patients: A Single-Center Bulgarian Study
Serum levels of specific immunoglobulin E and G to common food antigens and zonulin and their use in clinical practice for patients with IBS are investigated to help understand the mechanisms of IgG hypersensitivity and low degree inflammation in IBS and elevated z onulin may contribute to multifactor pathogenesis.
Colonic paracellular permeability and circulating zonulin-related proteins
The study suggests that neither circulating zonulin nor pre-HP2 mirror colonic permeability, and corroborate previous reports showing the inability of the CusabioZonulin kit to target zonul and highlights that the results of studies using this kit must be re-examined with caution.
Somatization in patients with predominant diarrhoea irritable bowel syndrome: the role of the intestinal barrier function and integrity
The GI symptoms profiles were significantly more severe, both as a single symptom and as clusters of IBS-SSS and GSRS, in HS than LS patients, suggesting a more pronounced imbalance of the small intestine in the former patients.
An updated overview of spectrum of gluten-related disorders: clinical and diagnostic aspects
The current definitions of gluten-related disorders, focusing on their clinical features, diagnostic and therapeutic approaches are presented and it is concluded that GRDs are usually diagnosed using a combination ofclinical features, serological tests, and histopathological findings.
Examination of plasma zonulin levels in bipolar I disorder: a case–control study with follow-up
Intestinal barrier integrity was not found to be altered among patients with BD type I and healthy controls, and plasma zonulin did not alter between the exacerbation and treatment response periods of the patients.
Profile of Intestinal Barrier Functional Markers in Italian Patients with Diarrhea-Predominant IBS: Preliminary Data from a Low-FODMAPs diet Trial
A low FODMAPs diet in patients with IBS-D reduced “abdominal pain”, “indigestion syndrome’, and “diarrhea syndrome” GSRS symptom clusters after 90 days of treatment, and improves intestinal functions, possibly moderating the excessive presence of serum and fecal zonulin, regulating mucosal inflammation, and imbalance in the dysbiosis fermentation processes.
Nonceliac Gluten and Wheat Sensitivity.
Non-celiac gluten sensitivity: All wheat attack is not celiac
The aim of this paper is to review the current understanding of non-celiac gluten sensitivity, highlighting the remaining challenges and questions which may improve its diagnosis and treatment.
Faecal biomarker patterns in patients with symptoms of irritable bowel syndrome
Frequency of abnormal results for elastase, calprotectin, eosinophil protein X, and beneficial organisms rose significantly with age, and differed significantly across IBS phenotypes, suggesting faecal biomarker testing is an appropriate means of identifying potentially treatable causes of IBS symptoms.