247 Relationship of Binding and Metabolic Disposition to Internalization of Insulin

Abstract

Previous studies by others have demonstrated internalization and lysosomal degradation of insulin in isolated cells, following binding to membrane receptors. In the present studies, the perfused rat liver was used to study the relationship between internalization, binding and metabolic disposition of I125 insulin. Washed, human RBC in 4% BSA and KRB were… (More)
DOI: 10.1203/00006450-198104001-00257

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