24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain.

  title={24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain.},
  author={Kristine L. Clark and Wayne Sebastianelli and Klaus R Flechsenhar and Douglas F. Aukermann and F{\'e}lix Alejandro Castellanos Meza and Roberta L. Millard and John R. Deitch and Paul S. Sherbondy and Ann Albert},
  journal={Current medical research and opinion},
  volume={24 5},
BACKGROUND Collagen hydrolysate is a nutritional supplement that has been shown to exert an anabolic effect on cartilage tissue. Its administration appears beneficial in patients with osteoarthritis. OBJECTIVE To investigate the effect of collagen hydrolysate on activity-related joint pain in athletes who are physically active and have no evidence of joint disease. DESIGN AND SETTING A prospective, randomized, placebo-controlled, double-blind study was conducted at Penn State University in… 

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Role of collagen hydrolysate in bone and joint disease.
  • R. Moskowitz
  • Medicine
    Seminars in arthritis and rheumatism
  • 2000
Collagen hydrolysate is of interest as a therapeutic agent of potential utility in the treatment of osteoarthritis and osteoporosis, and its high level of safety makes it attractive as an agent for long-term use in these chronic disorders.
Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders:a review of the literature
A growing body of evidence provides a rationale for the use of collagen hydrolysate for patients with OA and suggests mechanisms that might help patients affected by joint disorders such as OA.
What a difference a year makes: Reflections on the ACR recommendations for the medical management of osteoarthritis
The availability of the cyclo-oxygenase 2 (COX-2)-specific inhibitors and their documented greater safety relative to traditional dual-inhibitor NSAIDs with regard to serious upper gastrointestinal toxicity lead us to reassess the use of traditional NSAIDs in patients with OA, especially in those at increased risk for such adverse events.
Impact of Collagen Fragments on the Synthesis and Degradation of the Extracellular Matrix of Cartilage Tissue
Results clearly indicate a significant dosedependent, stimulatory effect of CH on the type II collagen biosynthesis of chondrocytes and a significant increase in the amount of pericellular proteoglycans could be observed.
Oral administration of (14)C labeled gelatin hydrolysate leads to an accumulation of radioactivity in cartilage of mice (C57/BL).
Inter intestinal absorption and cartilage tissue accumulation of gelatin hydrolysate are demonstrated and a potential mechanism for previously observed clinical benefits of orally administered gelatin is suggested.
Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen
Results clearly indicate a stimulatory effect of degraded collagen on the type II collagen biosynthesis of chondrocytes and suggest a possible feedback mechanism for the regulation of collagen turnover in cartilage tissue.
Persorption, Thieme-Verlag; Stuttgart
  • 1972
Zur unterstützenden Therapie bei Osteo- und Chondropathien [On supportive therapy for osteo- and chondropathy
  • Z Erfahrungsheikunde
  • 1979
Ernährungsmedizin und Diätetik
  • 2000