24-Hydroxylase: potential key regulator in hypervitaminosis D3 in growing dogs.

  title={24-Hydroxylase: potential key regulator in hypervitaminosis D3 in growing dogs.},
  author={Marianna A Tryfonidou and Marja A. Oosterlaken-dijksterhuis and Jan A. Mol and Ted S. G. A. M. van den Ingh and Walter E van den Brom and Herman A. W. Hazewinkel},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={284 3},
A group of growing dogs supplemented with cholecalciferol (vitamin D(3); HVitD) was studied vs. a control group (CVitD; 54,000 vs. 470 IU vitamin D(3)/kg diet, respectively) from 3 to 21 wk of age. There were no differences in plasma levels of P(i) and growth-regulating hormones between groups and no signs of vitamin D(3) intoxication in HVitD. For the duration of the study in HVitD vs. CVitD, plasma 25-hydroxycholecalciferol levels increased 30- to 75-fold; plasma 24,25… CONTINUE READING


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