24, 25-Dihydroxyvitamin D is a metabolite of vitamin D essential for bone formation

@article{Ornoy1978242D,
  title={24, 25-Dihydroxyvitamin D is a metabolite of vitamin D essential for bone formation},
  author={Asher Ornoy and David A. Goodwin and Dina Noff and Samuel Edelstein},
  journal={Nature},
  year={1978},
  volume={276},
  pages={517-519}
}
THE question whether vitamin D acts directly at sites of bone formation or indirectly at sites of calcium and phosphate absorption has long been a source of argument, with no general conclusion reached. Treatment of rachitic chicks with 1-hydroxyvitamin D3, the synthetic analogue of 1,25-dihydroxyvitamin D3, does not prevent most of the changes seen in bone affected by rickets, in spite of normal plasma levels of calcium and inorganic phosphate (unpublished). Similar findings have been reported… CONTINUE READING
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