221 Glucagon and Cyclic-amp Action on Gluconeogenesis in Hepatocytes from Suckling and Adult Rats

Abstract

The dose response to exogenous glucagon (10−9 to 5 X 10−7M) and Cyclic-AMP (10−5 to 10−3M) on gluconeogenesis from 5mM lactate was determined during incubation of hepatocytes from fed or fasted sucklings (S) (16 - 19 days old) and adult rats (A). Hepatocytes from fed sucklings had a blunted response to glucagon when compared to fed adult cells (% over basal… (More)
DOI: 10.1203/00006450-198104001-00230

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