22-ene-25-oxa-vitamin D: a new vitamin D analogue with profound immunosuppressive capacities.

  title={22-ene-25-oxa-vitamin D: a new vitamin D analogue with profound immunosuppressive capacities.},
  author={Carolin Daniel and Tobias Schlauch and Ulrich Zuegel and Andreas Steinmeyer and Heinfried H Radeke and Dieter Steinhilber and Juergen Stein},
  journal={European journal of clinical investigation},
  volume={35 5},
BACKGROUND The biologic role of 1,25-dihydroxyvitamin D(3), such as anti-inflammatory functions, reduction of cytokine production by T cells and immunoglobulin production by B cells, is well established. However, its clinical use as an immunosuppressive agent is limited because of the hypercalcemic toxicity occurring after systemic application. The purpose of this study was to investigate the immunmodulatory effects of 22-ene-25-oxa-vitamin D (ZK156979), a novel low calcemic vitamin D analogue… CONTINUE READING


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