22,23-Epoxy-2-aza-2,3-dihydrosqualene derivatives: potent new inhibitors of squalene 2,3-oxide-lanosterol cyclase.

Abstract

Two new azasqualenoid derivatives, bearing a 22,23 epoxidic function, were synthesized, to obtain more efficient, competitive inhibitors of the enzyme squalene 2,3-oxide-lanosterol cyclase (EC 5.4.99.7). The activities of 22,23-epoxy-2-aza-2,3-dihydrosqualene 4 and of its N-oxide derivative 5 were studied using rat and pig liver microsomal preparations and… (More)

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@article{Viola19902223Epoxy2aza23dihydrosqualeneDP, title={22,23-Epoxy-2-aza-2,3-dihydrosqualene derivatives: potent new inhibitors of squalene 2,3-oxide-lanosterol cyclase.}, author={Franca Viola and Maurizio Ceruti and Gianni Balliano and Otto Caputo and Luigi Cattel}, journal={Farmaco}, year={1990}, volume={45 9}, pages={965-78} }