-216G/T (rs712829), a functional variant of the EGFR promoter, is associated with the pleural metastasis of lung adenocarcinoma

@inproceedings{Guo2013216GTA,
  title={-216G/T (rs712829), a functional variant of the EGFR promoter, is associated with the pleural metastasis of lung adenocarcinoma},
  author={Haisheng Guo and Yunhui Xing and Ruibao Liu and Shaoping Chen and Xia Bian and Fang Wang and Chunmei Yang and Xunguo Wang},
  booktitle={Oncology letters},
  year={2013}
}
Numerous mutations and variants in the epidermal growth factor receptor (EGFR) gene have been demonstrated to be associated with the occurrence, metastasis and prognosis of various types of tumors, including lung cancer. Thus, the present study aimed to investigate whether -216G/T (rs712829), a functional polymorphism of the EGFR promoter that is able to induce EGFR activation and overexpression, is associated with the pleural metastasis of lung adenocarcinoma. The study subjects were comprised… CONTINUE READING