213. Protective and damaging effects of mediators of stress and adaptation: Central role of the brain

@article{McEwen2011213PA,
  title={213. Protective and damaging effects of mediators of stress and adaptation: Central role of the brain},
  author={Bruce McEwen},
  journal={Brain, Behavior, and Immunity},
  year={2011},
  volume={25}
}
Although the neurobiology of treatment resistant depression (TRD) is poorly understood, a number of factors have been associated with antidepressant non-response including obesity, early life stress, personality disorders, bipolar depression and medical co-morbidity. One pathophysiologic mechanism that may link these factors with TRD is inflammation. In addition to a direct relationship between inflammatory markers and TRD, increased inflammation is associated with depression in obesity, early… CONTINUE READING

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