2008 Update From the Collaborative Islet Transplant Registry

@article{Alejandro20082008UF,
  title={2008 Update From the Collaborative Islet Transplant Registry},
  author={Rodolfo Alejandro and Franca B. Barton and Bernhard J. Hering and Stephen Wease},
  journal={Transplantation},
  year={2008},
  volume={86},
  pages={1783-1788}
}
Background. This report summarizes the primary efficacy and the safety outcomes of islet transplantation reported to the NIDDK and JDRF funded Collaborative Islet Transplant Registry (CITR), currently the most comprehensive collection of human-to-human islet transplant data. Methods. CITR collects and monitors comprehensive data on allogeneic islet transplantation in North America, Europe, and Australia since 1999. Results. As of April 2008, the CITR registry comprised 325 adult recipients of… 

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References

SHOWING 1-4 OF 4 REFERENCES

The Islet Transplant Experiment: Time for a Reassessment

Sober reassessment of the clinical applicability of this protocol and particular experiment is needed because of the continued insulin dependence, the shortage of donor organs, the complications of immunosuppression, and the great expense of this procedure.

International Trial of the Edmonton Protocol for Islet Transplantation

Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen.

The observations in patients with type 1 diabetes indicate that islet transplantation can result in insulin independence with excellent metabolic control when glucocorticoid-free immunosuppression is combined with the infusion of an adequate islet mass.