2008 Alzheimer’s disease facts and figures

@article{Association20082008AD,
  title={2008 Alzheimer’s disease facts and figures},
  author={Alzheimer’s Association},
  journal={Alzheimer's \& Dementia},
  year={2008},
  volume={4},
  pages={110-133}
}
Adult Day Health Care for Participants With Alzheimer’s Disease
TLDR
Results demonstrate that ADHC providers are adapting to the cognitive and physical abilities of their participants; however, there is need for enhancing stage-specific services, especially for participants at later stages and for early-onset dementia.
Pathology of Neurodegenerative Diseases
As the average life expectancy has been extended by the current state-of-art medical technologies, the elderly population is increasing rapidly. The world is now facing the ‘ageing era’, which comes
Traumatic Brain Injury: Risk Factors and Biomarkers of Alzheimer's Disease and Chronic Traumatic Encephalopathy
  • R. Rubenstein
  • Biology, Medicine
    Current Translational Geriatrics and Experimental Gerontology Reports
  • 2012
TLDR
In almost all of the studies investigating traumatic brain injury and AD risk, AD was diagnosed based on clinical criteria for probable or possible AD, without neuropathological verification, suggesting that the increased incidence of dementia following head injuries is due to CTE, alone or in conjunction with other neurodegenerative conditions such as AD.
Cardiometabolic Modification of Amyloid Beta in Alzheimer’s Disease Pathology
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The contributions of individual cardiometabolic diseases including cardiovascular disease (CVD), type 2 diabetes (T2D), obesity, and non-alcoholic fatty liver disease (NAFLD) in elevating concentrations of circulating Aβ within the brain are highlighted, as well as the comorbid association of Aβ with AD pathology is discussed.
Mild cognitive impairment associates with concurrent decreases in serum cholesterol and cholesterol-related lipoprotein subclasses
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Findings suggest that a decreasing trend in serum cholesterol measures in elderly individuals may suffice as an indication for more detailed inspection for potential signs of cognitive decline.
Perceived Stigma in Caregivers of Persons with Dementia and its Impact on Depressive Symptoms
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It was found that caregivers of persons with dementia felt more depressed when they perceived more stigma after adjusting for other covariates in the model, and perceived stigma minimally mediated the effect between caregivers’ reactions toward the PwD’s memory and behavior symptoms and depressive symptoms.
Negotiating the Joint Career: Couples Adapting to Alzheimer's and Aging in Place
TLDR
Community services and care practices must be sensitive to the ways that couples prioritized and organized their relationship prior to diagnosis in order to encourage positive patterns of care between couples, foster successful adaptation to changing needs, and support in-home arrangements as long as possible.
C-terminal peptides coassemble into Aβ42 oligomers and protect neurons against Aβ42-induced neurotoxicity
TLDR
Aβ(31–42) and Aβ(39-42) are leads for obtaining mechanism-based drugs for treatment of AD using a systematic structure–activity approach.
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