2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference

  title={2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference},
  author={Mitchell M. Levy and Mitchell P. Fink and John C. Marshall and Edward Abraham and Derek C. Angus and Deborah J. Cook and Jonathan Cohen and Steven M. Opal and Jean Louis Vincent and G. Ramsay},
  journal={Critical Care Medicine},
ObjectiveIn 1991, the American College of Chest Physicians (ACCP) and the Society of Critical Care Medicine (SCCM) convened a “Consensus Conference,” the goals of which were “to provide a conceptual and a practical framework to define the systemic inflammatory response to infection, which is a progressive injurious process that falls under the generalized term ‘sepsis’ and includes sepsis-associated organ dysfunction as well.” The general definitions introduced as a result of that conference… 
[The definition of sepsis. 25-year experience of concept development].
The review, presented in chronological order the stages of formation of the modern definition of sepsis syndrome, since the recommendations of the conciliation conference ACCP/SCCM (1991), the
Organ dysfunction as a new standard for defining sepsis
The pathophysiology of sepsis and organ dysfunction is summarized and potential directions for future research are discussed and a drastic change in clinical definition is assumed.
CE: Managing Sepsis and Septic Shock: Current Guidelines and Definitions.
The new SSC treatment guidelines, changes in the sepsis bundle interventions, and the Sepsis-3 definitions and tools, all of which enable nurses to improve patient outcomes through timely collaborative action are discussed.
Clinical review: RIFLE and AKIN – time for reappraisal
There remains some variation in how the criteria are interpreted and used in the literature, including use/nonuse of urine output criteria, use of change in estimated glomerular filtration rate rather than change in Creatinine, and choice of baseline creatinine.
The International Sepsis Forum Consensus Conference on Definitions of Infection in the Intensive Care Unit
Consensus definitions of infection were developed for the six most frequent causes of infections in septic patients: pneumonia, bloodstream infections (including infective endocarditis), intravascular catheter-related sepsis, intra-abdominal infections, urosepsi, and surgical wound infections.
Controversies Regarding the New Definition of Sepsis
The Third International Consensus Definitions for Sepsis and Septic Shock (SEPSIS-3) task force assessed the latest pathophy-siological parameters associated with sepsis and septic shock and defined
The Japanese guidelines for the management of sepsis
This guideline was developed on the basis of evidence-based medicine and focuses on unique treatments in Japan that have not been included in the Surviving Sepsis Campaign guidelines (SSCG), as well as treatments that are viewed differently in Japan and in Western countries.
Update on pediatric sepsis: a review
A recently published global epidemiologic study (the SPROUT study) did not only reveal the demographics, therapeutic interventions, and prognostic outcomes but also elucidated the inappropriateness of the current definition of pediatric sepsis.
Validation of the new Sepsis-3 definitions: proposal for improvement in early risk identification.


American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis
Broad definitions of sepsis and the systemic inflammatory response syndrome were proposed, along with detailed physiologic variables by which a patient could be categorized, and the use of severity scoring methods were recommended when dealing with septic patients as an adjunctive tool to assess mortality.
SIRS and MODS: what is their relevance to the science and practice of intensive care?
As concepts, SIRS and MODS provide a useful intellectual framework for investigation, but the clinician must treat diseases, no acronyms, the challenge will be to characterize these disease.
Clinical practice parameters for hemodynamic support of pediatric and neonatal patients in septic shock*
American College of Critical Care Medicine adult guidelines for hemodynamic support of septic shock have little application to the management of pediatric or neonatal septicshock.
An international sepsis survey: a study of doctors' knowledge and perception about sepsis
There is a general awareness about the inadequacy of the current definitions of sepsis and Physicians caring for patients with sepsIS recognise the difficulty of defining and diagnosing sepsi and are aware that they miss the diagnosis frequently.
Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
Severe sepsis is a common, expensive, and frequently fatal condition, with as many deaths annually as those from acute myocardial infarction, and is especially common in the elderly and is likely to increase substantially as the U.S. population ages.
Nomenclature and criteria for diagnosis of ischemic heart disease. Report of the Joint International Society and Federation of Cardiology/World Health Organization task force on standardization of clinical nomenclature.
  • Medicine
  • 1979
The task of this group is to propose an internationally acceptable nomenclature of IHD and to define the underlying concepts in order to promote comparability of various studies.
Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome.
This multiple organ dysfunction score, constructed using simple physiologic measures of dysfunction in six organ systems, mirrors organ dysfunction as the intensivist sees it and correlates strongly with the ultimate risk of ICU mortality and hospital mortality.
Epidemiology of sepsis and multiple organ dysfunction syndrome in children.
The presence of SIRS, sepsis, or septic shock is associated with a distinct risk of mortality among critically ill children admitted to the pediatric ICU; more data are needed concerning children with MODS.
Development of a Pediatric Multiple Organ Dysfunction Score
The PELOD system was more discriminant than the PEMOD system and had the advantage of taking into ac count both the relative severities among ODs and the degree of severity of each OD.