2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference

  title={2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference},
  author={Mitchell M. Levy and Mitchell P. Fink and John C. Marshall and Edward Abraham and Derek C. Angus and Deborah J. Cook and Jonathan Cohen and Steven M. Opal and Jean Louis Vincent and G. Ramsay and for the International Sepsis Definitions Conference},
  journal={Intensive Care Medicine},
ObjectiveIn 1991, the American College of Chest Physicians (ACCP) and the Society of Critical Care Medicine (SCCM) convened a "Consensus Conference," the goals of which were to "provide a conceptual and a practical framework to define the systemic inflammatory response to infection, which is a progressive injurious process that falls under the generalized term 'sepsis' and includes sepsis-associated organ dysfunction as well. [] Key Method This conference was sponsored by the Society of Critical Care…

Evolving Definition and Diagnostic Criteria of Sepsis

SOFA scoring system is an easily calculated system using parameters that are usually obtained during routine care of patients, making it reproducible in any number of healthcare settings.

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).

The task force concluded the term severe sepsis was redundant and updated definitions and clinical criteria should replace previous definitions, offer greater consistency for epidemiologic studies and clinical trials, and facilitate earlier recognition and more timely management of patients with sepsi or at risk of developing sepsic shock.

Organ dysfunction as a new standard for defining sepsis

The pathophysiology of sepsis and organ dysfunction is summarized and potential directions for future research are discussed and a drastic change in clinical definition is assumed.

Clinical review: RIFLE and AKIN – time for reappraisal

There remains some variation in how the criteria are interpreted and used in the literature, including use/nonuse of urine output criteria, use of change in estimated glomerular filtration rate rather than change in Creatinine, and choice of baseline creatinine.

How many general and inflammatory variables need to be fulfilled when defining sepsis due to the 2003 SCCM/ESICM/ACCP/ATS/SIS definitions in critically ill surgical patients: a retrospective observational study

A cut-off of 3/8 variables is needed to identify almost all patients with septic shock who may benefit from optimal treatment, according to a retrospective observational single-centre study in postoperative/posttraumatic patients admitted to an adult ICU.

The International Sepsis Forum Consensus Conference on Definitions of Infection in the Intensive Care Unit

Consensus definitions of infection were developed for the six most frequent causes of infections in septic patients: pneumonia, bloodstream infections (including infective endocarditis), intravascular catheter-related sepsis, intra-abdominal infections, urosepsi, and surgical wound infections.

What is new in Sepsis

The Third International consensus definition for sepsis and septic shock defined in a manner sufficient enough to create awareness about early diagnosis of sepsic shock among health care professionals, so that mortality in sepsi can be reduced to some extent with proper intervention.

The New Sepsis Definitions: Implications for Critical Care Practitioners.

  • R. KleinpellC. SchorrR. Balk
  • Medicine
    American journal of critical care : an official publication, American Association of Critical-Care Nurses
  • 2016
This article reviews highlights of the new sepsis definitions, including implications for practicing critical care clinicians, and uses clinical criteria for sepsi surveillance and identification based on prior consensus definitions.

Different patient case mix by applying the 2003 SCCM/ESICM/ACCP/ATS/SIS sepsis definitions instead of the 1992 ACCP/SCCM sepsis definitions in surgical patients: a retrospective observational study

The prevalence and mortality rates of various sepsis severity stages differ if defined by the 1992 or the 2003 definitions, and transferring conclusions drawn from data sets regarding severity of sepsi generated with the 1992 definitions to the same population applying the2003 definitions may be misleading.



Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine.

Broad definitions of sepsis and the systemic inflammatory response syndrome were proposed, along with detailed physiologic parameters by which a patient may be categorized, and the use of severity scoring methods when dealing with septic patients was recommended as an adjunctive tool to assess mortality.

SIRS and MODS: what is their relevance to the science and practice of intensive care?

As concepts, SIRS and MODS provide a useful intellectual framework for investigation, but the clinician must treat diseases, no acronyms, the challenge will be to characterize these disease.

The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure

A so-called sepsis-related organ failure assessment (SOFA) score is created to describe quantitatively and as objectively as possible the degree of organ dysfunction/failure over time in groups of patients or even in individual patients.

Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care

Severe sepsis is a common, expensive, and frequently fatal condition, with as many deaths annually as those from acute myocardial infarction, and is especially common in the elderly and is likely to increase substantially as the U.S. population ages.

Clinical practice parameters for hemodynamic support of pediatric and neonatal patients in septic shock*

American College of Critical Care Medicine adult guidelines for hemodynamic support of septic shock have little application to the management of pediatric or neonatal septicshock.

Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome.

This multiple organ dysfunction score, constructed using simple physiologic measures of dysfunction in six organ systems, mirrors organ dysfunction as the intensivist sees it and correlates strongly with the ultimate risk of ICU mortality and hospital mortality.

Epidemiology of sepsis and multiple organ dysfunction syndrome in children.

The presence of SIRS, sepsis, or septic shock is associated with a distinct risk of mortality among critically ill children admitted to the pediatric ICU; more data are needed concerning children with MODS.

Development of a Pediatric Multiple Organ Dysfunction Score

The PELOD system was more discriminant than the PEMOD system and had the advantage of taking into ac count both the relative severities among ODs and the degree of severity of each OD.

Usefulness of procalcitonin as a marker of systemic infection in emergency department patients: a prospective study.

We prospectively evaluated serum procalcitonin concentrations in patients who presented to an emergency department (ED) with suspected infectious or inflammatory disease. Of 195 study patients, 68

Treatment of Septic Shock with Human Monoclonal Antibody HA-1A

A large, simple trial design to test the use of septic shock as an indication for HA-1A treatment and the effectiveness of 100 mg of HA- 1A and placebo in reducing the 14-day all-cause mortality rate in patients with sepsis who had gram-negative bacteremia was tested.