20-fold increase in risk of lamivudine resistance in hepatitis B virus subtype adw.

@article{Zoellner200120foldII,
  title={20-fold increase in risk of lamivudine resistance in hepatitis B virus subtype adw.},
  author={Bernhard Zoellner and J{\"o}rg Petersen and Matthias L. Schroeter and Rainer Laufs and Volker U Schoder and H H Feucht},
  journal={Lancet},
  year={2001},
  volume={357 9260},
  pages={934-5}
}
We investigated subtype-dependent development of lamivudine resistance in hepatitis B virus (HBV) longitudinally in 26 consecutive patients (13 adw and 13 ayw carriers) during antiviral treatment of chronic hepatitis B. Lamivudine resistance developed in seven adw carriers and one ayw carrier. Risk of lamivudine resistance was significantly higher for adw carriers than for ayw carriers (p=0.03). We believe that the adw subtype of HBV is associated with a high risk of lamivudine resistance… CONTINUE READING

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