20-Hydroxyeicosatetraenoic acid stimulates nuclear factor-kappaB activation and the production of inflammatory cytokines in human endothelial cells.

@article{Ishizuka200820HydroxyeicosatetraenoicAS,
  title={20-Hydroxyeicosatetraenoic acid stimulates nuclear factor-kappaB activation and the production of inflammatory cytokines in human endothelial cells.},
  author={Tsuneo Ishizuka and Jennifer Cheng and Harpreet Singh and Marco D Vitto and Vijay L. Manthati and John R Falck and Michal Laniado-Schwartzman},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2008},
  volume={324 1},
  pages={103-10}
}
Endothelial dysfunction is associated with endothelial cell activation, i.e., up-regulation of surface cell adhesion molecules and the release of proinflammatory cytokines. 20-Hydroxyeicosatetraenoic acid (HETE), a major vasoactive eicosanoid in the microcirculation, has been implicated in the regulation of endothelial cell function through its angiogenic and pro-oxidative properties. We examined the effects of 20-HETE on endothelial cell activation in vitro. Cells transduced with adenovirus… CONTINUE READING

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