20-Hydroxyecdysone decreases weight and hyperglycemia in a diet-induced obesity mice model.

@article{Kizelsztein200920HydroxyecdysoneDW,
  title={20-Hydroxyecdysone decreases weight and hyperglycemia in a diet-induced obesity mice model.},
  author={Pablo Kizelsztein and Dmitry Govorko and Slavko Komarnytsky and Alysa Evans and Zhong dong Wang and William T. Cefalu and Ilya Raskin},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2009},
  volume={296 3},
  pages={
          E433-9
        }
}
The steroid hormone 20-hydroxyecdysone (20HE) is an essential signaling molecule that modulates molting response in insects and may function as a putative anabolic factor in vertebrate animals, although no mammalian 20HE receptor has been identified. Here we show that in H4IIE cell culture, 20HE treatment decreased expression of phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase), reduced glucose production, and induced Akt2 phosphorylation sensitive to the… CONTINUE READING

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