20-HETE is an endogenous inhibitor of the large-conductance Ca(2+)-activated K+ channel in renal arterioles.

@article{Zou199620HETEIA,
  title={20-HETE is an endogenous inhibitor of the large-conductance Ca(2+)-activated K+ channel in renal arterioles.},
  author={A P Zou and John T Fleming and John R Falck and Elizabeth R. Jacobs and Debebe Gebremedhin and David R. Harder and Richard J. Roman},
  journal={The American journal of physiology},
  year={1996},
  volume={270 1 Pt 2},
  pages={R228-37}
}
The present study examined the effects of 20-hydroxyeicosatetraenoic acid (20-HETE) and 17-octadecynoic acid (17-ODYA), an inhibitor of the metabolism of arachidonic acid by P-450, on K(+)-channel activity in vascular smooth muscle cells (VSM) isolated from renal arterioles of the rat. Two types of K+ channels were characterized using inside-out excised membrane patches. One channel exhibited a large conductance (250.3 +/- 5 pS), was activated by membrane depolarization and elevations in… CONTINUE READING

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