20-HETE inhibits the proliferation of vascular smooth muscle cells via transforming growth factor-beta.

@article{Liang200820HETEIT,
  title={20-HETE inhibits the proliferation of vascular smooth muscle cells via transforming growth factor-beta.},
  author={Chan-Jung Liang and Harlan E. Ives and Chuen-Mao Yang and Yunn-Hwa Ma},
  journal={Journal of lipid research},
  year={2008},
  volume={49 1},
  pages={66-73}
}
20-Hydroxyeicosatetraenoic acid (20-HETE), a cytochrome P450 arachidonic acid metabolite, has been shown to modulate the growth of vascular smooth muscle cells (VSMCs). We asked whether 20-HETE modulates the proliferation of R22D cells, a clonal VSMC from neonatal rats, by releasing transforming growth factor-beta (TGF-beta). Incubation of R22D cells with 20-HETE for 24 h attenuated [(3)H]thymidine incorporation in a concentration-dependent manner without causing the release of lactate… CONTINUE READING