20-HETE increases superoxide production and activates NAPDH oxidase in pulmonary artery endothelial cells.

@article{Medhora200820HETEIS,
  title={20-HETE increases superoxide production and activates NAPDH oxidase in pulmonary artery endothelial cells.},
  author={Meetha M Medhora and Yuenmu Chen and Stephanie K Gruenloh and Daniel Harland and Sreedhar Bodiga and Jacek Zielonka and Debebe Gebremedhin and Ying Gao and John R Falck and Siddam Anjaiah and Elizabeth R. Jacobs},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2008},
  volume={294 5},
  pages={L902-11}
}
Reactive oxygen species (ROS) signal vital physiological processes including cell growth, angiogenesis, contraction, and relaxation of vascular smooth muscle. Because cytochrome P-450 family 4 (CYP4)/20-hydroxyeicosatetraenoic acid (20-HETE) has been reported to enhance angiogenesis, pulmonary vascular tone, and endothelial nitric oxide synthase function, we explored the potential of this system to stimulate bovine pulmonary artery endothelial cell (BPAEC) ROS production. Our data are the first… CONTINUE READING

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