20-HETE and EETs in Diabetic Nephropathy: A Novel Mechanistic Pathway

  title={20-HETE and EETs in Diabetic Nephropathy: A Novel Mechanistic Pathway},
  author={St{\'e}phanie A Eid and Rita Maalouf and Ayad A. Jaffa and Joseph Nassif and Ahmed Hamdy and Awad Rashid and Fuad N. Ziyadeh and Assaad A Eid},
  booktitle={PloS one},
Diabetic nephropathy (DN), a major complication of diabetes, is characterized by hypertrophy, extracellular matrix accumulation, fibrosis and proteinuria leading to loss of renal function. Hypertrophy is a major factor inducing proximal tubular epithelial cells injury. However, the mechanisms leading to tubular injury is not well defined. In our study, we show that exposure of rats proximal tubular epithelial cells to high glucose (HG) resulted in increased extracellular matrix accumulation and… CONTINUE READING
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