20-HETE agonists and antagonists in the renal circulation.

  title={20-HETE agonists and antagonists in the renal circulation.},
  author={Magdalena Alonso-Galicia and John R Falck and Komandla Malla Reddy and Richard J. Roman},
  journal={American journal of physiology. Renal physiology},
  volume={277 5},
The present study examined the effects of a series of 20-hydroxyeicosatetraenoic acid (20-HETE) derivatives on the diameter of renal arterioles to determine the structural requirements of the vasoconstrictor response to 20-HETE. The vascular responses to 5-, 8-, 12-, 15-, 19-, 20-, 21-HETEs, arachidonic acid (AA), and saturated, partially saturated, dimethyl, carboxyl, and 19-carbon derivatives of 20-HETE (10-8 to 10-6 M) were assessed in rat renal interlobular arteries (65-125 μm). 20-HETE, 21… CONTINUE READING
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