20-Epi analogues of 1,25-dihydroxyvitamin D3 are highly potent inducers of DRIP coactivator complex binding to the vitamin D3 receptor.

@article{Yang199920EpiAO,
  title={20-Epi analogues of 1,25-dihydroxyvitamin D3 are highly potent inducers of DRIP coactivator complex binding to the vitamin D3 receptor.},
  author={Wei Yang and Leonard P. Freedman},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 24},
  pages={16838-45}
}
1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) plays a major role in the stimulation of bone growth, mineralization, and intestinal calcium and phosphate absorption; it also acts as a general inhibitor of cellular proliferation. Several new, clinically relevant compounds dissociate antiproliferative and calcemic activities of 1,25(OH)2D3, but the molecular basis for this has not been clearly elucidated. Here, we tested whether the potency of one class of compounds, 20-epi analogues, to induce myeloid… CONTINUE READING
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Vitamin D: Gene Regulation, Structure-Function Analysis and Clinical Applications

  • Y. Nishii, J. Abe, +7 authors A. G. Raisz
  • 1991

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