20‐Residue and 11‐residue peptaibols from the fungus Trichoderma longibrachiatum are synergistic in forming Na+/K+‐permeable channels and adverse action towards mammalian cells

@article{Mikkola201220ResidueA1,
  title={20‐Residue and 11‐residue peptaibols from the fungus Trichoderma longibrachiatum are synergistic in forming Na+/K+‐permeable channels and adverse action towards mammalian cells},
  author={Raimo Mikkola and Maria A Andersson and L{\'a}szl{\'o} Kredics and Pavel A. Grigoriev and Nina Sundell and Mirja S. Salkinoja-Salonen},
  journal={The FEBS Journal},
  year={2012},
  volume={279}
}
Certain species of the filamentous fungal genus Trichoderma (e.g. Trichoderma longibrachiatum and Trichoderma citrinoviride) are among the emerging clinical pathogens and also the most common species in the indoor space of mould‐damaged buildings. The molecules involved in its pathology are not known. In the present study, we report that 0.5–2.6 wt% of the T. longibrachiatum mycelial biomass consisted of thermostable secondary metabolites mitochondriotoxic to mammalian cells. These were… 
Identification and Biological Activities of Long‐Chain Peptaibols Produced by a Marine‐Derived Strain of Trichoderma longibrachiatum
TLDR
Six long‐chain peptaibols, 1 – 6, were identified from agar cultures of a marine‐derived Trichoderma longibrachiatum Rifai strain isolated from blue mussels, and three new sequences were identified and were calledLongibrachins A‐0, A‐II‐a, and A‐IV‐b.
Sequences of Metanicins, 20‐Residue Peptaibols from the Ascomycetous Fungus CBS 597.80
TLDR
Four linear 20‐residue peptaibols, named metanicins (MTCs) A–D, were isolated from submerged cultures of the ascomycetous fungus and showed moderate activities against Micrococcus luteus, Enterococcus faecalis, and Staphylococcus aureus, and very low activities against Bacillus subtilis.
Longibramides A–E, Peptaibols Isolated from a Mushroom Derived Fungus Trichoderma longibrachiatum Rifai DMG‐3‐1‐1
Five new peptaibols, longibramides A–E (1–5) with 11 amino acid residues, were isolated from a fungus Trichoderma longibrachiatum Rifai DMG‐3‐1‐1, which was isolated from a mushroom Clitocybe
Peptaibol, Secondary‐Metabolite, and Hydrophobin Pattern of Commercial Biocontrol Agents Formulated with Species of the Trichoderma harzianum Complex
TLDR
Five commercial biocontrol agents formulated with recently described species of the Trichoderma harzianum complex were analyzed, and it could unequivocally be demonstrated that all of these formulations contained new and recurrent peptaibols, i.e.,peptaibiotics carrying an acetylated N‐terminus, the C‐ terminus of which is reduced to a 1,2‐amino alcohol.
Zealpeptaibolin, an 11-mer cytotoxic peptaibol group with 3 Aib-Pro motifs isolated from Trichoderma sp. RK10-F026.
Six new 11-mer peptaibols designed as zealpeptaibolins, A - F were isolated from the soil fungus, Trichoderma sp. RK10-F026, based on the principal component analysis of the MS data from five
Rapid bioactivity-based pre-screening method for the detection of peptaibiotic-producing Trichoderma strains
TLDR
A rapid, bacterium-based screening method was developed and optimized for the detection of peptai- biotic production in liquid cultures of Trichoderma strains, validated with the commercially available alamethicin as a peptaibiotic reference compound.
Changes in Peptaibol Production of Trichoderma Species during In Vitro Antagonistic Interactions with Fungal Plant Pathogens
TLDR
The interaction with plant pathogens highly influenced the peptaibol production of the examined Trichoderma strains, with an increase in the total amount of peptaIBols produced during the interactions, as well as some differences in the peptibol profiles between the confrontational and control tests.
Trichoderma lixii (IIIM-B4), an endophyte of Bacopa monnieri L. producing peptaibols
TLDR
Optimization studies were carried out on T. lixii (IIIM-B4) using different growth media through Intact Cell Mass Spectrometry (ICMS) and a multifold increase was obtained in production of 11 residue peptaibols using rose bengal medium, which was found to have antifungal activity against Candida albicans.
Peptaibols from Trichoderma asperellum TR356 strain isolated from Brazilian soil
TLDR
The results indicate the production of two classes of peptaibols for this T. asperellum strain, an antibiotic peptide group characterized by the presence of non-proteinogenic amino acids such as α-aminoisobutyrate (Aib) and amino alcohols in the C-terminal region.
Toxic indole alkaloids avrainvillamide and stephacidin B produced by a biocide tolerant indoor mold Aspergillus westerdijkiae.
TLDR
Avrainvillamide and stephacidin B represent a new class of toxins with possible a threat to human health in buildings and a role of nitrone group in the mechanism of toxicity is indicated.
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TLDR
This approach established a new lineage in Trichoderma/Hypocrea, the Brevicompactum clade, comprising four new and one redescribed species, and future prospects regarding novel bioactivities and further research needs, including interdisciplinary taxonomic approaches are outlined.
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Evidence is provided that the 14‐module NRPS type found in T. virens, T. reesei (teleomorph Hypocrea jecorina), and T. atroviride produces both 11‐ and 14‐residue peptaibols based on the disruption of the respective NRPS gene of T.Reesei, and bioinformatic analysis of their amino acid‐activating domains and modules.
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TLDR
Monitoring production and degradation of peptaibiotics in a pilot experiment revealed that the biosynthesis of TB II and TB III peptides starts two days after the beginning of fermentation, which unequivocally demonstrates that those two 18‐residue TB I and TB II peptides with the free carboxy terminus result from enzymatic C‐terminal degradation of the 20‐resido peptides.
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TLDR
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TLDR
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TLDR
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Two Classes of New Peptaibols Are Synthesized by a Single Non-ribosomal Peptide Synthetase of Trichoderma virens*
TLDR
An unprecedented case where a single NRPS encodes for two classes of peptaibols produced by the biocontrol fungus Trichoderma virens is presented and could have applications as therapeutic agents for the management of human and plant health.
New Sequences, Constituents, and Producers of Peptaibiotics: An Updated Review
TLDR
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From the culture broth of the mold Trichoderma viride, strain 63 C‐I, the polypeptide antibiotic suzukacillin (SZ) was isolated. A peptide mixture named SZ‐A was obtained by crystallization from
Sequences of alamethicins F30 and F50 reconsidered and reconciled
TLDR
From the culture broth of the mould Trichoderma viride, strain NRRL 3199, a microheterogeneous mixture of the membrane active 20‐residue peptaibol alamethicin (ALM) could be isolated and sequences of the neutral peptide mixture named ALM F50 could be determined.
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