2-hydroxyoleic acid: a new hypotensive molecule.

@article{Alemany20042hydroxyoleicAA,
  title={2-hydroxyoleic acid: a new hypotensive molecule.},
  author={Regina Alemany and Silvia Ter{\'e}s and Carmela Baamonde and Mikhail Benet and Oliver V{\"o}gler and Pablo V. Escrib{\'a}},
  journal={Hypertension},
  year={2004},
  volume={43 2},
  pages={249-54}
}
Recent studies have shown that diets rich in monounsaturated fatty acids (MUFAs) from olive oil, a natural source of oleic acid, have beneficial effects on blood pressure (BP) in hypertensive patients. With this in mind, we investigated whether a synthetic derivative of the MUFA oleic acid, 2-hydroxyoleic acid (2-OHOA), was capable of regulating the BP of Sprague-Dawley rats. Intraperitoneal and oral administration of 2-OHOA to rats induced significant and sustained decreases in BP in a time… CONTINUE READING

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