2-hydroxy-5-carbomethoxybenzyloxyamine: a new potent inhibitor of histidine decarboxylase.

  title={2-hydroxy-5-carbomethoxybenzyloxyamine: a new potent inhibitor of histidine decarboxylase.},
  author={Zsuzsanna Huszti and Endre Dr Kasztreiner and Marianne K{\"u}rti and M{\'a}rton I. K. Fekete and J{\'o}zsef Borsy},
  journal={Biochemical pharmacology},
  volume={22 18},
Peptide inhibition of mammalian histidine decarboxylase
It is concluded that small peptides with histidine as theN-terminal amino acid might act as specific inhibitors for mammalian histidine decarboxylase.
Effect of histidine decarboxylase inhibitors and other drugs on histamine formation in vivo
Only one drug, 4-imidazole-3-amino-2-butanone showed strong activity in both skin and stomach samples; it did not affect brain histamine formation, possibly because it does not enter brain.
Induction of gastric histamine synthesis by H2-receptor antagonists: Potentiation of their antisecretory activity by histidine decarboxylase inhibitors
Findings provided evidence for the feedback stimulation of gastric HA synthesis by H2-receptor blockers and confirmed the role of HA in the gastric acid secretion.
Regulation of histamine synthesis: Metiamide-induced synthesis of histamine in the rat stomach and the effect of histidine decarboxylase inhibitors on the elevated14C-histamine level and histidine decarboxylase activity
The splitstream technique was employed and it was possible to analyse simultaneously radioactive metabolites in physiological fluids or tissue extracts and to determine the non-labelled amine content in the same sample thus saving much time and finding hitherto unknown compounds in biological samples.
Effects ofl-histidine administration on the concentrations of histidine and histamine in various tissues
Larger amounts of histidine could reserve the histamine reducing actions of these inhibitors but this effect seems to be related to a competition between histidine and these compounds for the active site of the enzyme.
Possible involvement of endogenous histamine in the myotropic effect of clonidine on the isolated rabbit aorta
Clonidine has a contractile effect in the isolated rabbit aorta which can be blocked by alpha-adrenergic antagonist, phentolamine. Histamine H1-receptor blocker, mepyramine, partly antagonizes its
Urinary oxalate levels are not affected by dietary purine intake or allopurinol.
Investigation of ingestion of a non-specific high purine diet by healthy subjects under carefully controlled dietary conditions confirmed that one of the beneficial effects of allopurinol was to reduce dietary purine absorption, and may provide a logical explanation for the reduced incidence of urolithiasis in some idiopathic oxalate stone formers addicted to purine-rich foods and beverages.


The chemical estimation of tyrosine and tyramine.
Inhibition of tissue histamine formation by decaborane.
The data suggest that decaborane may depress histamine levels by inhibiting histidine decarboxylase and that brain histamine may exist in different metabolic pools.
Experiments on the inhibition of histamine formation in the rat.
Experimental work on inhibition of histamine formation in vivo originates in two prerequisite advances: the elucidation of the biogenesis of tissue and urinary histamine and the elaboration of
A spectrophotometric method for determination of diamine oxidase (DAO) activity.
Simultaneously determinations of diamine oxidase in different dilutions have been carried out using this colorimetric method and the Warburg technique.
A method for the fluorometric assay of histamine in tissues.
Gross dissection of brain showed no marked localization of brain histamine and a sensitive and specific fluorometric method for the estimation of histamine in tissues was described.
Determination of diamine oxidase activity by liquid scintillation counting.