2-deoxy-d-ribose induces apoptosis by inhibiting the synthesis and increasing the efflux of glutathione.

@article{Fico20082deoxydriboseIA,
  title={2-deoxy-d-ribose induces apoptosis by inhibiting the synthesis and increasing the efflux of glutathione.},
  author={Annalisa Fico and Genesia Manganelli and Luisa Cigliano and Paolo Bergamo and Paolo Abrescia and Claudio Franceschi and Giuseppe Martini and Stefania Filosa},
  journal={Free radical biology & medicine},
  year={2008},
  volume={45 2},
  pages={211-7}
}
Oxidative stress is caused by imbalance between the production of reactive oxygen species (ROS) and biological system ability to readily detoxify the reactive intermediates or repair the resulting damage. 2-deoxy-D-ribose (dRib) is known to induce apoptosis by provoking an oxidative stress by depleting glutathione (GSH). In this paper, we elucidate the mechanisms underlying GSH depletion in response to dRib treatment. We demonstrated that the observed GSH depletion is not only due to inhibition… CONTINUE READING

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