2-deoxy-ATP enhances contractility of rat cardiac muscle.

@article{Regnier20002deoxyATPEC,
  title={2-deoxy-ATP enhances contractility of rat cardiac muscle.},
  author={Michael Regnier and Anthony J Rivera and Yu Chen and P. Bryant Chase},
  journal={Circulation research},
  year={2000},
  volume={86 12},
  pages={1211-7}
}
To investigate the kinetic parameters of the crossbridge cycle that regulate force and shortening in cardiac muscle, we compared the mechanical properties of cardiac trabeculae with either ATP or 2-deoxy-ATP (dATP) as the substrate for contraction. Comparisons were made in trabeculae from untreated rats (predominantly V1 myosin) and those treated with propylthiouracil (PTU; V3 myosin). Steady-state hydrolytic activity of cardiac heavy meromyosin (HMM) showed that PTU treatment resulted in >40… CONTINUE READING
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The calcium sensitivity of steady - state force and force development kinetics in cardiac muscle is enhanced by 2 deoxy - ATP ( dATP )

  • M Regnier, DA Martyn, PB Chase
  • Biophys J
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The calcium sensitivity of steady-state force and force development kinetics in cardiac muscle is enhanced by 2 deoxy-ATP (dATP).Biophys

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Cross-bridge regulation of force development in chemically skinned rat trabeculae

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Enhancement of filament sliding speed by 2-deoxy ATP is greater in cardiac muscle than in skeletal muscle

  • M Regnier, Y Chen, PB. Chase
  • Biophys J. 1999;76:A312
  • 1999

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