2-aryloxy-4-alkylaminopyridines: discovery of novel corticotropin-releasing factor 1 antagonists.

@article{Chen20082aryloxy4alkylaminopyridinesDO,
  title={2-aryloxy-4-alkylaminopyridines: discovery of novel corticotropin-releasing factor 1 antagonists.},
  author={Yuhpyng Liang Chen and R Scott Obach and John P. Braselton and Michael Leon Corman and Jonathan A Forman and Jody K Freeman and Randall J. Gallaschun and Robert S. Mansbach and Anne W. Schmidt and Jeffrey Scott Sprouse and F David Tingley and Elizabeth M Winston and David W. Schulz},
  journal={Journal of medicinal chemistry},
  year={2008},
  volume={51 5},
  pages={
          1385-92
        }
}
An orally active clinical candidate of corticotropin-releasing factor 1 (CRF 1) antagonist 1 showed a significant positive food effect in dog and human after oral administration. Efforts to address the food effect issue led us to explore and discover compounds in series 2 as orally active CRF 1 receptor antagonists, in which some compounds showed improved physicochemical properties while retaining desired pharmacological properties. Compound 3a (CP-376395) was selected for further development… CONTINUE READING
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