2-arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor.

  title={2-arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor.},
  author={Lum{\'i}r Ondřej Hanu{\vs} and Saleh Abu-Lafi and Ester Fride and Aviva Breuer and Zvi Vogel and Deborah E. Shalev and Irina Kustanovich and Raphael Mechoulam},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={98 7},
Two types of endogenous cannabinoid-receptor agonists have been identified thus far. They are the ethanolamides of polyunsaturated fatty acids--arachidonoyl ethanolamide (anandamide) is the best known compound in the amide series--and 2-arachidonoyl glycerol, the only known endocannabinoid in the ester series. We report now an example of a third, ether-type endocannabinoid, 2-arachidonyl glyceryl ether (noladin ether), isolated from porcine brain. The structure of noladin ether was determined… CONTINUE READING
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