2-Thiazolylethylamine, a selective histamine H1 agonist, decreases seizure susceptibility in mice.

@article{Yokoyama19942ThiazolylethylamineAS,
  title={2-Thiazolylethylamine, a selective histamine H1 agonist, decreases seizure susceptibility in mice.},
  author={Hisayuki Yokoyama and Kenji Onodera and Kazuie Iinuma and Takehiko Watanabe},
  journal={Pharmacology, biochemistry, and behavior},
  year={1994},
  volume={47 3},
  pages={503-7}
}
The effects of intracerebroventricular (ICV) administration of histamine and its selective agonists on electrically and pentylenetetrazole-induced convulsions in mice were studied. The ICV administration of histamine decreased seizure susceptibility on electrically and pentylenetetrazole-induced convulsions significantly and dose-dependently. The inhibitory effects of histamine were well antagonized by centrally acting histamine H1 antagonists such as pyrilamine (or mepyramine) and ketotifen… CONTINUE READING

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