2 Subunit Specificity of Cyclothiazide Inhibition on Glycine Receptors


In the mammalian cortex, 2 subunit-containing glycine receptors (GlyRs) mediate tonic inhibition, but the precise functional role of this type of GlyRs is difficult to establish because of the lack of subtype-selective antagonist. In this study, we found that cyclothiazide (CTZ), an epileptogenic agent, potently inhibited GlyR-mediated current (IGly) in… (More)

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