2-Oxoglutarate-dependent oxygenases control hepcidin gene expression.

@article{Braliou20082OxoglutaratedependentOC,
  title={2-Oxoglutarate-dependent oxygenases control hepcidin gene expression.},
  author={Georgia G. Braliou and Maria Vittoria Verga Falzacappa and Georgia Chachami and Guillem Casanovas and Martina U. Muckenthaler and George Simos},
  journal={Journal of hepatology},
  year={2008},
  volume={48 5},
  pages={801-10}
}
BACKGROUND/AIMS Hepcidin is a liver-produced hormone that regulates systemic iron homeostasis. Hepcidin expression is stimulated upon iron overload or inflammation while iron deficiency, anemia and tissue hypoxia are negative regulators. We investigated the involvement of 2-oxoglutarate-dependent oxygenases, HIF-1 and other transcription factors in the hypoxic suppression of hepcidin. METHODS Northern blotting analysis and real time PCR were used to determine hepcidin mRNA levels in hepatoma… CONTINUE READING

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