2-Oxo acid dehydrogenase complexes in redox regulation.

  title={2-Oxo acid dehydrogenase complexes in redox regulation.},
  author={Victoria I. Bunik},
  journal={European journal of biochemistry},
  volume={270 6},
A number of cellular systems cooperate in redox regulation, providing metabolic responses according to changes in the oxidation (or reduction) of the redox active components of a cell. Key systems of central metabolism, such as the 2-oxo acid dehydrogenase complexes, are important participants in redox regulation, because their function is controlled by the NADH/NAD+ ratio and the complex-bound dihydrolipoate/lipoate ratio. Redox state of the complex-bound lipoate is an indicator of the… CONTINUE READING


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