2-Nicotinamidoethyl acetate (SG-209) is a potassium channel opener: Structure activity relationship among nicorandil derivatives

Abstract

The mechanism of the vasodilating action of 2-nicotinamidoethyl acetate (SG-209), a derivative of nicorandil, was examined in the isolated rabbit aorta. Comparison was made using 2-nicotinamidoethyl alcohol (SG-86) and 2-nicotinamidoethyl nitrate (nicorandil; SG-75) to reveal any structure-activity relationships. SG-209 and nicorandil caused concentration… (More)
DOI: 10.1007/BF00167224

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