2-Methylsorbic acid, an antifungal metabolite of Penicillium vermiculatum

  title={2-Methylsorbic acid, an antifungal metabolite of Penicillium vermiculatum},
  author={Bohumil Proksa and Jana Adamcov{\'a} and J{\'a}n Fuska},
  journal={Applied Microbiology and Biotechnology},
2-Methylsorbic acid (MA), (2Z,4E)-2-methyl-2,4-hexadienoic acid, is a new metabolite of Penicillium vermiculatum. Antifungal activity of this acid was higher than that of sorbic acid or the bromoderivatives bromomethylsorbic acid and bromosorbic acid. MA suppressed the growth of Talaromyces flavus and germination of its conidia. In P. vermiculatum this acid lowered production of vermiculin and inhibited proteosynthesis in Saccharomyces cerevisiae.