2-Methylcitric acid impairs glutamate metabolism and induces permeability transition in brain mitochondria.

@article{Amaral20162MethylcitricAI,
  title={2-Methylcitric acid impairs glutamate metabolism and induces permeability transition in brain mitochondria.},
  author={Alexandre Umpierrez Amaral and Cristiane Cecatto and Roger F Castilho and Moacir Wajner},
  journal={Journal of neurochemistry},
  year={2016},
  volume={137 1},
  pages={62-75}
}
Accumulation of 2-methylcitric acid (2MCA) is observed in methylmalonic and propionic acidemias, which are clinically characterized by severe neurological symptoms. The exact pathogenetic mechanisms of brain abnormalities in these diseases are poorly established and very little has been reported on the role of 2MCA. In the present work we found that 2MCA… CONTINUE READING