2-Methoxyestradiol reverses doxorubicin resistance in human breast tumor xenograft

@article{Azab20082MethoxyestradiolRD,
  title={2-Methoxyestradiol reverses doxorubicin resistance in human breast tumor xenograft},
  author={Samar Saad Eldeen Azab and Salama A. Salama and Memy Hegazy Hassan and Amani E. Khalifa and Ebtehal el-Demerdash and Hala M Fouad and Ayman A Al-Hendy and Ashraf B Abdel-Naim},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2008},
  volume={62},
  pages={893-902}
}
2-Methoxyestradiol (2ME), an endogenous estradiol metabolite, was developed as a novel agent based on its antitumor activity and lack of toxicity. This study was designed to investigate the modulatory effect of 2ME on the antitumor effect of doxorubicin (Dox) in resistant breast tumor xenograft. Resistant MCF-7/Dox cells were implanted subcutaneously in nude mice Treatment with Dox 5 mg/kg, 2ME 30 mg/kg and their combination continued twice a week for 2 weeks. Following 28 days from starting… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 36 references

The pharmacology of cancer resistance

  • R O’Connor
  • Anticancer Res
  • 2007
1 Excerpt

A (2004) In vitro and in vivo antitumor effect of 2methoxyestradiol on human melanoma

  • J Dobos, J Tı́már, +5 authors Ladányi
  • Int J Cancer
  • 2004
1 Excerpt

In vitro and in vivo antitumor effect of 2methoxyestradiol on human melanoma

  • J Dobos, J Tı́már, +5 authors A Ladányi
  • Int J Cancer
  • 2004

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