2-Methoxyestradiol reduces monocyte adhesion to aortic endothelial cells in ovariectomized rats.

  title={2-Methoxyestradiol reduces monocyte adhesion to aortic endothelial cells in ovariectomized rats.},
  author={Atsuko Kurokawa and Kosuke Azuma and Tomoya Mita and Yukiko Toyofuku and Yoshio Fujitani and Takahisa Hirose and Kazuhisa Iwabuchi and Hideoki Ogawa and Satoru Takeda and Ryuzo Kawamori and Hirotaka Watada},
  journal={Endocrine journal},
  volume={54 6},
2-Methoxyestradiol (2-ME) is an endogenous metabolite of estradiol with no affinity for estrogen receptors. It inhibits cell proliferation, thus is a potentially useful drug to block the progression of atherosclerosis. As a first step to examining the anti-atherosclerotic effects of 2-ME, we investigated monocyte adhesion to aortic endothelial cells, which is considered a prerequisite to atherosclerosis in vivo. Eight-week-old Sprague-Dawley rats were ovariectomized then treated by slow-release… CONTINUE READING
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Tivesten A (2007) The endogenous estradiol metabolite 2-methoxyestradiol reduces atherosclerotic lesion formation in female ApoE-deficient mice

  • J Bourghardt, G Bergstrom, A Krettek, S Sjoberg, J Boren
  • Endocrinology
  • 2007
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