2-Methoxyestradiol (2-ME) reduces the airway inflammation and remodeling in an experimental mouse model.

Abstract

Patients with asthma experience airway structural changes, termed airway remodeling, in response to persistent inflammation. 2-Methoxyestradiol (2-ME) is an anti-angiogenic agent and downregulates hypoxia-inducible factor 1 (HIF-1) and inhibits HIF-1alpha-induced transcriptional activation of vascular endothelial growth factor (VEGF) expression. We… (More)
DOI: 10.1016/j.clim.2008.07.023

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