Corpus ID: 8673192

2-Iodoimipramine, a novel ligand for the serotonin transporter.

  title={2-Iodoimipramine, a novel ligand for the serotonin transporter.},
  author={C. J. Humphreys and D. Cassel and G. Rudnick},
  journal={Molecular pharmacology},
  volume={36 4},
  • C. J. Humphreys, D. Cassel, G. Rudnick
  • Published 1989
  • Chemistry, Medicine
  • Molecular pharmacology
  • Iodoimipramine was synthesized by iodinating imipramine with ICI. Iodoimipramine competitively inhibits [3H]imipramine binding with a KI of 0.52 nM and also inhibits [3H]serotonin transport competitively, suggesting that serotonin, imipramine, and iodoimipramine all bind to the same site on the serotonin transporter. Association of [125I]iodoimipramine to platelet membranes in Na+ requires 20 min to reach equilibrium at 25 degrees and 1.5 hr at 0 degrees. [125I] Iodoimipramine binding at… CONTINUE READING
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