2-Deoxy-D-glucose reduces epilepsy progression by NRSF-CtBP–dependent metabolic regulation of chromatin structure

@article{GarrigaCanut20062DeoxyDglucoseRE,
  title={2-Deoxy-D-glucose reduces epilepsy progression by NRSF-CtBP–dependent metabolic regulation of chromatin structure},
  author={Mireia Garriga-Canut and Barry Schoenike and Romena Qazi and Karen Bergendahl and Timothy J Daley and Rebecca M Pfender and J. F. J. Morrison and Jeffrey C. Ockuly and Carl E. Stafstrom and Thomas P. Sutula and Avtar S. Roopra},
  journal={Nature Neuroscience},
  year={2006},
  volume={9},
  pages={1382-1387}
}
Temporal lobe epilepsy is a common form of drug-resistant epilepsy that sometimes responds to dietary manipulation such as the 'ketogenic diet'. Here we have investigated the effects of the glycolytic inhibitor 2-deoxy-D-glucose (2DG) in the rat kindling model of temporal lobe epilepsy. We show that 2DG potently reduces the progression of kindling and blocks seizure-induced increases in the expression of brain-derived neurotrophic factor and its receptor, TrkB. This reduced expression is… 

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