2-Deoxy-D-glucose reduces epilepsy progression by NRSF-CtBP–dependent metabolic regulation of chromatin structure

@article{GarrigaCanut20062DeoxyDglucoseRE,
  title={2-Deoxy-D-glucose reduces epilepsy progression by NRSF-CtBP–dependent metabolic regulation of chromatin structure},
  author={M. Garriga-Canut and B. Schoenike and R. Qazi and K. Bergendahl and Timothy J Daley and Rebecca M Pfender and J. Morrison and J. Ockuly and C. Stafstrom and T. Sutula and A. Roopra},
  journal={Nature Neuroscience},
  year={2006},
  volume={9},
  pages={1382-1387}
}
Temporal lobe epilepsy is a common form of drug-resistant epilepsy that sometimes responds to dietary manipulation such as the 'ketogenic diet'. Here we have investigated the effects of the glycolytic inhibitor 2-deoxy-D-glucose (2DG) in the rat kindling model of temporal lobe epilepsy. We show that 2DG potently reduces the progression of kindling and blocks seizure-induced increases in the expression of brain-derived neurotrophic factor and its receptor, TrkB. This reduced expression is… Expand
Seizure suppression via glycolysis inhibition with 2‐deoxy‐D‐glucose (2DG)
Fructose-1,6-diphosphate inhibits seizure acquisition in fast hippocampal kindling
2-Deoxyglucose and Beta-Hydroxybutyrate: Metabolic Agents for Seizure Control
The Biochemistry and Epigenetics of Epilepsy: Focus on Adenosine and Glycine
  • D. Boison
  • Biology, Medicine
  • Front. Mol. Neurosci.
  • 2016
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