• DOI:10.1038/nn1791
Corpus ID: 10175791

2-Deoxy-D-glucose reduces epilepsy progression by NRSF-CtBP–dependent metabolic regulation of chromatin structure

@article{GarrigaCanut20062DeoxyDglucoseRE,
  title={2-Deoxy-D-glucose reduces epilepsy progression by NRSF-CtBP–dependent metabolic regulation of chromatin structure},
  author={M. Garriga-Canut and B. Schoenike and R. Qazi and K. Bergendahl and Timothy J Daley and Rebecca M Pfender and J. Morrison and J. Ockuly and C. Stafstrom and T. Sutula and A. Roopra},
  journal={Nature Neuroscience},
  year={2006},
  volume={9},
  pages={1382-1387}
}

• M. Garriga-Canut, B. Schoenike, +8 authors A. Roopra
• Published 2006
• Biology, Medicine
• Nature Neuroscience

Temporal lobe epilepsy is a common form of drug-resistant epilepsy that sometimes responds to dietary manipulation such as the 'ketogenic diet'. Here we have investigated the effects of the glycolytic inhibitor 2-deoxy-D-glucose (2DG) in the rat kindling model of temporal lobe epilepsy. We show that 2DG potently reduces the progression of kindling and blocks seizure-induced increases in the expression of brain-derived neurotrophic factor and its receptor, TrkB. This reduced expression is… Expand

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