Corpus ID: 718165

2-Deoxy-D-glucose alters the cardio-respiratory parameters in anaesthetized rats.

@article{Pandey20082DeoxyDglucoseAT,
  title={2-Deoxy-D-glucose alters the cardio-respiratory parameters in anaesthetized rats.},
  author={Ratna Pandey and P K Choudhry and Shripad Bhimarao Deshpande},
  journal={Indian journal of physiology and pharmacology},
  year={2008},
  volume={52 3},
  pages={
          243-8
        }
}
2-Deoxy-D-Glucose (2-DG), a synthetic analogue of glucose, is used as an anticancer agent either alone or in combination with other tumor treatment protocols. The present study was conducted to identify the systemic effects of 2-DG on parameters of vital importance. The blood pressure, ECG and respiratory excursions were recorded in anesthetized adult rats. At the end (after 120 min) of experiments, the plasma glucose and serum insulin levels were estimated. Injection of 2-DG (0.5 g/kg… Expand
2-Deoxy-d-Glucose (2-DG)–Induced Cardiac Toxicity in Rat
TLDR
NT-proBNP and BNP are potential early biomarkers for 2-DG-induced cardiac toxicity that can be useful to monitor 2- DG therapy in clinical trials. Expand

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