2-Deoxy-D-galactose effects on passive avoidance memorization in the rat.

  title={2-Deoxy-D-galactose effects on passive avoidance memorization in the rat.},
  author={C G Lorenzini and Elisabetta Baldi and Corrado Bucherelli and Benedetto Sacchetti and Giovanna Tassoni},
  journal={Neurobiology of learning and memory},
  volume={68 3},
2-Deoxy-D-galactose (do-gal) hinders glycoprotein fucosylation. This compound was intracerebroventricularly administered to male adult Wistar rats in order to assess whether it could exert amnesic effects on a passive avoidance response (PAR) to be learned in the light-dark box apparatus. Three experiments were performed. In the first, do-gal was administered immediately after the acquisition trials at three dosages (2, 4, and 8 mumol). It was found that only the 4-mumol dosage was followed by… CONTINUE READING