2-Bromo-6-isocyanopyridine as a Universal Convertible Isocyanide for Multicomponent Chemistry.

@article{Heijden20162Bromo6isocyanopyridineAA,
  title={2-Bromo-6-isocyanopyridine as a Universal Convertible Isocyanide for Multicomponent Chemistry.},
  author={Gydo van der Heijden and J. A. W. Jong and E. Ruijter and R. Orru},
  journal={Organic letters},
  year={2016},
  volume={18 5},
  pages={
          984-7
        }
}
The development of 2-isocyanopyridines as novel convertible isocyanides for multicomponent chemistry is reported. Comparison of 12 representatives of this class revealed 2-bromo-6-isocyanopyridine as the optimal reagent in terms of stability and synthetic efficiency. It combines sufficient nucleophilicity with good leaving group capacity of the resulting amide moiety under both basic and acidic conditions. To demonstrate the practical utility of this reagent, an efficient two-step synthesis of… Expand
2-Nitrobenzyl Isocyanide as a Universal Convertible Isocyanide.
...
1
2
3
...

References

SHOWING 1-10 OF 32 REFERENCES
Multicomponent reactions of convertible isonitriles.
Versatile, fragrant, convertible isonitriles.
Synthesis of heterocycles by formal cycloadditions of isocyanides.
...
1
2
3
4
...