2-Arachidonoylglycerol impairs human cytotrophoblast cells syncytialization: influence of endocannabinoid signalling in placental development.

@article{Costa20152ArachidonoylglycerolIH,
  title={2-Arachidonoylglycerol impairs human cytotrophoblast cells syncytialization: influence of endocannabinoid signalling in placental development.},
  author={Marta Aline Coelho da Costa and Elisa Keating and Bruno M. Fonseca and Nat{\'e}rcia A A Teixeira and Georgina Correia-da-Silva},
  journal={Molecular and cellular endocrinology},
  year={2015},
  volume={399},
  pages={386-94}
}
A balanced cytotrophoblast cell turnover is crucial for placental development and anomalies in this process associated with gestational diseases. The endocannabinoid system (ECS) has emerged as a new player in several biological processes. However, its influence during placental development is still unknown. We report here the expression of the endocannabinoid 2-arachidonoylglycerol (2-AG) main metabolic enzymes in human cytotrophoblasts and syncytiotrophoblast. We also showed that 2-AG induced… CONTINUE READING